Network interactions mediated by new excitatory connections between ca1
pyramidal cells in rats with kainate-induced epilepsy.
Smith, Bret N., and F. Edward Dudek.
Department of Anatomy and Neurobiology, Program in Molecular, Cellular and
Integrative Neuroscience, Colorado State University, Fort Collins, CO 80523, USA.
APStracts 8:0426J, 2001.
Axon sprouting and synaptic reorganization in the hippocampus are associated with the
development of seizures in temporal lobe epilepsy. Synaptic interactions among CA1
pyramidal cells were examined in fragments of hippocampal slices containing only the
CA1 area from saline- and kainate-treated rats. Glutamate microapplication to the
pyramidal cell layer increased EPSC frequency, but only in rats with kainate-induced
epilepsy. In bicuculline, action potentials evoked in single pyramidal cells increased the
frequency of network bursts only in slices from rats with kainate-induced epilepsy.
These data further support the hypothesis that excitatory connections between CA1
pyramidal cells increase after kainate-induced status epilepticus.
Received 16 July 2001; accepted in final form 29 October 2001
APS Manuscript Number J581-1.
Article publication pending Am J Physiol
ISSN 1080-4757 Copyright 2001 The American Physiological Society.
Published in APStracts on 26 December 2001